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The Role of Oxidative Stress in Lipoedema and Chronic Lymphoedema

  • Jeanine Mewburn
  • 11 minutes ago
  • 3 min read

Oxidative stress is a natural by-product of cellular metabolism — in simple terms, it occurs when the body produces energy from food and oxygen. During this process, unstable molecules called free radicals are formed. Oxidative stress can be worsened by exposure to pollutants such as cigarette smoke, alcohol, pesticides, and by a poor diet.


The body is equipped with protective mechanisms known as antioxidants, which help neutralise free radicals. Problems arise when there is an imbalance — when free radicals outnumber antioxidants. This imbalance can lead to damage to cells and DNA, particularly in tissues that have a reduced oxygen supply such as in lymphoedema and lipoedema.


Research suggests that oxidative stress plays a significant role in the progression of chronic lymphoedema. Fluid accumulation and poorly oxygenated tissues increase free radical production, which can damage lymphatic vessels and promote ongoing inflammation. Similarly, oxidative stress is thought to contribute to chronic inflammation and fibrosis in lipoedema.


Studies indicate that strengthening the body’s antioxidant defences may be beneficial in managing lymphoedema. A 2013 case study reported positive outcomes in a patient with both lipoedema and lymphoedema when treated with a combination of selenium and Butcher’s Broom. It is also worth noting that many selenium-rich foods are compatible with a ketogenic diet, which some clinicians recommend for lipoedema management.


However, it is essential that selenium or any antioxidant supplementation is only undertaken after blood levels have been checked, as excessive supplementation can be harmful.


A diet naturally rich in antioxidants — including vitamins C and E, flavonoids, and omega-3 fatty acids — found in fruits, vegetables, whole grains, legumes, and healthy fats, may help support overall health and contribute to disease prevention.


Understanding the role of oxidative stress in lipoedema and chronic lymphoedema highlights the importance of a holistic approach to management. Supporting lymphatic health is not only about reducing swelling, but also about improving tissue oxygenation, calming inflammation, and protecting the lymphatic system from ongoing damage. While nutrition and targeted antioxidant support can play a role, these strategies are most effective when combined with appropriate clinical care and individualised treatment plans.


With many years of experience working with lymphoedema and lipoedema — including post-surgical care — I provide gentle, evidence-based manual lymphatic drainage massage, compression garment measuring and fitting, and ongoing education to support long-term lymphatic health. Each treatment is tailored to your individual needs, with a focus on reducing inflammation, supporting tissue health, and improving quality of life.


If you would like guidance or support as part of your lymphoedema or lipoedema management, I am here to help.


Acts of kindness towards your body can lead to big results.



References


·       Borut Poljsak, D. Š. (2013 April 19). Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants. Oxid Med Cell Longev. doi:10.1155/2013/956792

·       Christina Pfister, H. D.-J. (2020 April 26). Selenium Deficiency in Lymphedema and Lipedema—A Retrospective Cross-Sectional Study from a Specialized Clinic. Nutrients - Pub Med Central. doi:10.3390/nu12051211

·       Christina Pfister, H. D.-J. (2020, April, 25). Selenium Deficiency in Lymphedema and Lipedema-A Retrospective Cross-Sectional Study from a Specialized Clinic. Pub Med. doi:10.3390/nu12051211.

·       Johnson Chia-Shen Yang, P.-J. K.-M.-C.-C.-C.-C.-H.-C. (2025, July, 29). Linking Lymphedema, Chronic Inflammation, Oxidative Stress, Alzheimer Disease, and Potential Role of Lymphaticovenous Anastomosis. International OpenAccess Journal of the American Society of Plastic Surgeons. doi:10.1097/GOX.000000000000695

·       Keith, L. (2024, September 5). Prevalence of Selenium Deficiency in Lymphatic Disorders. Retrieved February 4, 2026, from Lipoedema simplified: https://lipedema-simplified.org/selenium-deficiency/#:~:text=These%20findings%20open%20new%20avenues,selenium%20deficiency%20through%20appropriate%20testing.

·       Lazina Hossain, K. P. (2025, March). The microenvironment of secondary lymphedema. The key to finding. Bio Chimica et Biophysica Acta (BBA), 1871. Retrieved February 2, 2026, from https://www.sciencedirect.com/science/article/pii/S0925443925000225

·       Siems, W. B. (2002, December). Oxidative stress in chronic lymphoedema. Pub Med, 803-9. doi:10.1093/qjmed/95.12.803.

·       I am the author of this blog post with the assistance of ChatGPT to proofread and polish


 
 
 

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